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Information × Registration Number 0226U002645, (0124U001303) , R & D reports Title Innovative nanobiotechnology to accelerate the post-traumatic recovery of the musculoskeletal system functional activity popup.stage_title Механокінетичні дослідження функціонального стану скелетних м’язів щурів на тлі їх атрофічного переродження внаслідок ішемізації після механічної травми та дії водорозчинних С60 фулеренів залежно від дози і способу введення. Head Nozdrenko Dmytro М., Доктор біологічних наук Registration Date 02-03-2026 Organization Taras Shevchenko National University of Kyiv popup.description1 The purpose of the work: the development of the safe and effective technology for using water-soluble C60 fullerenes to reduce the consequences of pathological processes in skeletal muscles, caused by trauma and their subsequent atrophy, due to the long-term immobilization and ischemia, as well as the time required to fully restore the damaged skeletal muscle functioning. popup.description2 During military operations, more than 90% of all injuries to both military personnel and civilians are skeletal muscle injuries. In many cases, they lead to apoptosis and necrosis of muscle tissue. Inflammation induced by reactive oxygen species (ROS) begins almost immediately after muscle injury and accompanies the healing process. In cases of severe and extensive injuries, the body may not be able to cope on its own, so the additional use of artificial or natural antioxidants for therapeutic purposes will promote muscle function recovery. Therefore, the use of water-soluble C60 fullerenes, which can effectively neutralize excess ROS to prevent damage to cells and muscle tissue without affecting the main metabolic pathways to avoid side effects, can accelerate the recovery of skeletal muscle function after injury and subsequent atrophy. The goal is to develop a safe and effective technology for the use of water-soluble C60 fullerenes to reduce the effects of pathological processes in skeletal muscles caused by trauma and subsequent atrophy due to prolonged immobilization, as well as the time required for complete restoration of damaged skeletal muscle function. To achieve the goal, the following tasks were solved: to study the change in the force response of skeletal muscles of animals after mechanical trauma and their subsequent atrophy due to immobilization depending on the dose and method of administration of water-soluble C60 fullerenes, to establish the time intervals during which post-traumatic recovery of the functional activity of the skeletal muscles of animals occurs depending on the dose and method of administration of water-soluble C60 fullerenes. It is proposed to conduct systematic preclinical trials of water-soluble C60 fullerenes as potential therapeutic nanoagents that are simultaneously capable of reducing the severity of pathological processes in skeletal muscles after traumatic injury and the time of their functional recovery. Product Description popup.authors Yurii I. Prylutskyi Kateryna I. Bohutska Igor Pampuha Maksym S. Anhelov popup.nrat_date 2026-03-02 Close