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Information × Registration Number 0226U002685, (0123U101955) , R & D reports Title Molecular mechanisms of physical processes that determine the use of hydrogels in military medical technologies popup.stage_title Молекулярні механізми формування структурних дефектів у гідрогелі та їх роль у процесі регенерації пошкодженої біотканини. Head Kovalchuk Valerii I., Кандидат фізико-математичних наук Registration Date 03-03-2026 Organization Taras Shevchenko National University of Kyiv popup.description1 The purpose of the study is to determine the molecular mechanisms of physical processes that are the basis for the use of hydrogels in the restoration of damaged biological tissues and controlled kinetics of drug release and their delivery targeting. popup.description2 The work is aimed at creating the physical foundations of the latest military medical technologies based on various hydrogel systems, which will significantly improve the quality of drug use in emergency medicine and offer fundamentally new solutions for creating more reliable and cheaper nanocomposite hydrogels for paramedical applications. The object of study is the physical processes that occur in hydrogels when hydrogels are used for wound treatment. The aim of the work is to determine the molecular mechanisms of these processes. The sol-gel transition in aqueous solutions of cellulose derivatives with ion impurities was investigated. A model describing the kinetics of this process has been proposed. A model of the surface structure of the hydrogel has been created, and the absorption and mechanism of water transport through the surface of the hydrogel have been described. It has been shown that water movement in the surface layer of the gel is possible due to the existence of defects – vacancy complexes in the pore walls. The peculiarities of mesh formation in fibrin gels have been investigated, which can be used as a basis for the manufacture of medical materials for stopping bleeding. It has been experimentally proven that changes in temperature, glucose injections, and the action of a magnetic field affect the regeneration of damaged biological tissue. It has been established that in diluted aqueous solutions of cellulose derivatives at temperatures higher than the sol-gel transition temperature, in the presence of salts, significant supramolecular associates are formed, which can be used to create polymer films with antibacterial and fungicidal properties. A model of hydrophobic association of polymer molecules in solutions with salt ions has been proposed. It has been proven that water in a liquid state has anomalous properties at a temperature of 42°C, which is specific for living biotissues. Product Description popup.authors Leonid A. Bulavin Yurii F. Zabashta Shmelova Liudmyla V. Vitalii Y. Bardyk Rudnikov Yevhenii Н. Svechnikova Oksana S. Verhun Liena Yu. Iryna Doroshenko Yurii Н. Kuzovkov Mariia О. Sosnovska Ohorodnyk Kateryna О. Mykola І. Lebovka popup.nrat_date 2026-03-03 Close