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Information × Registration Number 0226U002791, (0123U100100) , R & D reports Title Hormonal-receptor status of tumor microenvironment cells as a factor in the modulation of oncogenesis in the endometrium and breast cancer popup.stage_title Оцінка зв’язку між експресією маркерів клітин раку молочної залози та компонентами пухлинного мікрооточення. Head Buchynska Liubov H., Доктор біологічних наук Registration Date 05-03-2026 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description1 To establish the role of steroid hormone receptors (estrogens and progesterone) in determining the phenotypic features of the microenvironment of endometrial and breast carcinomas associated with the aggressiveness of the tumor process. popup.description2 The influence of CXCL12, as a factor of the tumor microenvironment, on the expression of the main components of the c-Met/HGF signaling cascade and adhesion molecules CD326, CD227 and CD54 in breast cancer (BC) cell lines of different molecular subtypes was elucidated. For the first time, an increase expression of CD54, CD227, CD326 and HGF was established in the cells of the luminal molecular subtype T-47D, MCF-7, while in the cells of the triple negative molecular subtype MDA-MB-231 - an increase in the expression of CD54, c-Met along with a decrease in the expression of CD326 and HGF, which leads to an increase of cell malignancy. Incubation of MDA-MB-231 cells with CXCL12 leads to a slight increase in the content of cells in the S phase of the cell cycle due to a decrease in the content of cells in the G0/G phase, which indicates an increase in the proliferative potential of tumor cells. The results obtained expand the understanding of the mechanisms of the paracrine effect of CXCL12 on breast cancer cells, which may be a theoretical basis for the development of new approaches to blocking tumor progression. In breast cancer patients, an association of tumor cells with the TGFβ1highCXCL12lowCXCR4high phenotype, high content of TGFβ1⁺- and CXCL12⁺- fibroblasts, and the presence of metastases in regional lymph nodes has been established. The results obtained reflect the importance of cross-communication between parenchymal and stromal cells, which determines the metastatic potential of breast cancer. Product Description popup.authors Nataliia P. Yurchenko Maryna L. Marchenko Oleksii O. Filchenkov Mykhajlo P. Zavelevych Nadiia M. Hlushchenko Liudmyla Y. Poludnenko Larysa Shlapatska Tetiana P. Skybenko popup.nrat_date 2026-03-05 Close