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Information × Registration Number 0226U002908, (0125U001429) , R & D reports Title Study of mechanical and biological properties of polymer nanohydroxyapatite biodegradable 3D scaffolds in vitro and in vivo conditions popup.stage_title Синтез полімернаногідроксиапатитних біодеградуючих 3D скафолдів, визначення механічних властивостей і структурний аналіз поверхні матеріалів Head Oleshko Oleksandr M., Кандидат медичних наук Registration Date 09-03-2026 Organization Sumy State University popup.description1 Creation of new three-dimensional biodegradable porous polymer-hydroxyapatite scaffolds containing silver and zinc oxide nanoparticles by direct 3D printing, as well as studying and establishing the regularities of their formation, structure, physical, mechanical, and biological properties, which will allow for targeted control of the processes occurring in the studied materials during their synthesis, as well as improving the conditions for adhesion and proliferation of cells on the surface and in the structure of experimental scaffolds to stimulate osteogenesis during their operation popup.description2 During the research work, the following new scientific results were obtained: 1. Data about the composition and ratio of components in the control and experimental series of scaffolds. The method of combining PCL and PLA and their percentage ratios has been established. 2. Laboratory methods for synthesising biodegradable composites based on polymer plastics with the introduction of active fillers into the structure: hydroxyapatite and metal oxide nanoparticles. 3. 3D models and advanced algorithms for direct 3D printing with mode selection (printing temperature and speed, metric parameters of the printing fibre, internal structure architecture according to the percentage of filling) for the creation of three-dimensional polymer hydroxyapatite biodegradable scaffolds. 4. Series of control polymer and experimental multicomponent scaffolds. 5. Based on the results of scanning electron microscopy, it was found that the combination of polycaprolactone and polylactic acid led to the formation of a porous surface, which in turn can positively affect the intensity of cell adhesion, as well as increase the total surface area of the samples. 6. As a result of determining the mechanical properties of experimental samples according to ISO 527, it was found that an increase in the content of polycaprolactone leads to a decrease in stiffness and an increase in the plasticity of the multicomponent material. Product Description popup.authors Vladyslav A. Smiianov Oleksandr M. Oleshko Khrystyna V. Berladir Tetyana V. Kasyanenko Tetiana P. Hovorun Liudmyla B. Sukhodub Maksym S. Yermakov Tetiana V. Ivakhnyuk Victoriia V. Hlushchenko Vitalii R. Vasyliev Yaroslav V. Deineka Oksana P. Haponova Oleksandr V. Korol Andrii M. Nosov Oleksandr V. Kiriienko popup.nrat_date 2026-03-09 Close