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Information × Registration Number 0226U002910, (0125U000447) , R & D reports Title Prediction of the properties of multicomponent biodegradable scaffolds for the treatment and correction of bone tissue injuries popup.stage_title Створення і випробування на механічні властивості мультикомпонентних біодеградуючих скафолдів Head Oleshko Tetiana B., Кандидат медичних наук Registration Date 09-03-2026 Organization Sumy State University popup.description1 Creation of predictive machine learning algorithms for the production of multicomponent biodegradable scaffolds with predefined properties for the treatment and correction of bone tissue injuries popup.description2 During the research project, the following new scientific results were obtained: 1. Data on the composition of multicomponent biodegradable scaffolds with a wide variation in the ratios of polymer components, optimal concentrations of hydroxyapatite, and active functional nanofillers for the synthesis of polymer-nanohydroxyapatite scaffolds. Methodology for studying biopolymer nano-hydroxyapatite scaffolds obtained by direct 3D printing. 2. 3D models of biopolymer scaffolds using computer modelling for direct 3D printing. Improved 3D printing algorithm: temperature, fiber metric parameters, and printing speed, to obtain three-dimensional polymer-nanohydroxyapatite scaffolds. 3. Six series of multicomponent scaffolds with a wide variation in polymer component ratios, optimal concentrations of hydroxyapatite and active functional nanofillers, as well as different filling percentages. 4. Data from macro- and microstructural analysis of samples to confirm the relationships between the composition and structure of materials and 3D printing parameters. Based on scanning and raster electron microscopy, the structure of the printed scaffolds was found to be identical to the 3D models, confirming the appropriateness of the selected printing parameters, the purity of the synthesized material's composition, and the absence of foreign chemical elements. Fourier transform infrared spectroscopy was used to identify the peaks of the polymer bonds in polycaprolactone and polylactic acid. 5. Based on mechanical tests, it was proven that variations in nozzle temperature and changes in pore metric parameters within defined ranges do not have a statistically significant effect on the overall mechanical strength, which allows for flexible adjustment of these parameters to optimize porosity without loss of structural strength Product Description popup.authors Tetiana B. Oleshko Khrystyna V. Berladir Oleksandr S. Sokolov Victoriia V. Hlushchenko Yaroslav V. Deineka Dmytro O. Holub Oleksandr V. Korol Andrii M. Nosov Oleksandr V. Kiriienko Serhii A. Zaiats popup.nrat_date 2026-03-09 Close