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Information × Registration Number 0226U003126, (0121U113840) , R & D reports Title Study of the lactobacilli, bifidobacteria and opportunistic pathogens of the human microbiota influence on the features of mechanisms realization of metabolic disturbances in the tumor process (2.2.5.447) popup.stage_title Визначити вплив інгібіторів та індукторів бактеріального походження на особливості процесів метаболізму глюкози та окремі ключові ланки протипухлинної резистентності організму. Head Lykhova Oleksandra O., Кандидат біологічних наукChekhun Vasyl F., Доктор медичних наук Registration Date 17-03-2026 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description1 To determine the role of opportunistic pathogens of the human microbiota, lactobacilli and bifidobacteria in the metabolic processes of breast cancer cells with different degree of malignancy popup.description2 It has been proven for the first time that the microbiome is an active conductor of modulation of the effectiveness of the immunological response in conditions of malignant process. In particular, in the in vivo model system with transplanted Ehrlich carcinoma, L. rhamnosus GG bacteria contributed to the manifestation of low arginase activity, increased levels of NO and ROS production, which ensured the maintenance of a positive balance in the polarization of M1 macrophages and the increase in their cytotoxic activity, as a key link in nonspecific antitumor immunity. At the same time, B. animalis BB-12, while maintaining the level of NO production, contributed to a significant increase in the activity of arginase, IL-10 and a decrease in the level of TNF-α, which indicated an increase in the polarization of anti-inflammatory M2 macrophages and an increase in immunosuppression processes. The results obtained provide important information regarding the prospects for the use of probiotic products in the correction of the course of the tumor process and optimization of the effectiveness of patient therapy Product Description popup.authors Hetman Kateryna I. Symchych Tetiana V. Liudmyla M. Tyshchenko Hohol Serhii V. Tetiana V. Borikun Zhuk Oleksandr M. Iryna M. Voyeykova Nadiia L. Cheremshenko Nataliia I. Fedosova Oleksandr M. Mushii Kukurudza Dmytro V. Petro A. Virych Natalya Bezdieniezhnykh Kyrylo O. Saulenko Tamara P. Kozak Nataliia M. Verbinenko popup.nrat_date 2026-03-17 Close