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Information × Registration Number 0226U003169, (0123U102047) , R & D reports Title Fundamentals of the influence of immunomodulators, probiotics and nanomaterials on the pathogenetic mechanisms of the development of viral and microbial diseases popup.stage_title Відпрацювання експериментальних моделей вірусіндукованого патологічного процесу у лабораторних тварин та вивчення особливостей відповіді системи інтерферону за умови застосування ряду сполук з антиоксидантною активністю (в тому числі наноматеріалів). Встановлення імуномодулювальних, антимікробних та протизапальних властивостей пробіотичних культур, їх метаболітів та наноматеріалів на розроблених моделях змішаних інфекцій бактеріальної та грибкової природи, а також встановлення їх впливу на мікробіоту різних біотопів. Візуалізація за допомогою ТЕМ, біогенних Nano-Se синтезованих бактеріями роду Bacillus та Lactobacillus. Head Spivak Mykola Ya., Доктор біологічних наук Registration Date 19-03-2026 Organization Institute of Microbiology and Virology named after D. K. Zabolotny of the National Academy of Sciences of Ukraine popup.description1 The purpose of the work is to determine the pathogenetic mechanisms of the development of infectious processes of viral and microbial etiology, the course of which is accompanied by the development of the body's inflammatory reaction, as well as to establish the influence of immunomodulators, probiotics and nanomaterials on the pathogenetic mechanisms of their development. popup.description2 It was shown that under the influence of cerium dioxide nanoparticles (CeO₂, 0.1M) there was a gradual normalization of the vaginal microbiota of infected animals, in particular, the number of LAB increased against the background of the gradual elimination of pathogens of the infectious and inflammatory process. The composition of CeO₂ with probiotic strains of bacteria turned out to be promising, which accelerated the elimination of pathogens from the vagina, in particular microscopic fungi and Escherichia coli, and also contributed to the normalization of the number of LAB. It was established that aerobic bioreduction of selenium is inherent in certain strains of lactobacteria and bacteria of the species Bacillus subtilis, which are able to resist selenite using various detoxification mechanisms. Certain factors affecting the biosynthesis of Nano-Se nanoparticles (NPs) were determined, in particular the type of producer, cultivation conditions and time of their biosynthesis. It has been proven that the key factor of metabolic self-organization is the interaction between enzymes and metabolites of LAB. It has been established that the selected culture of Lactobacillus rhamnosus GR-1 is capable of transforming sodium selenite to the elemental state by an intracellular and extracellular mechanism of action. The biotransformation of sodium selenite by the probiotic culture of L. rhamnosus GR-1 indicates the involvement of lipopolysaccharides (LPS) and exopolysaccharides (EPS) in the extracellular reduction of selenite to Nano-Se. Biogenic Nano-Se synthesized by bacteria of the genus Bacillus and Lactobacillus was visualized using TEM. Product Description popup.authors Mykola Y. Spivak Trokhymchuk Tetiana Yu. Nadiia M. Zholobak Leonid P. Buchatskyi Bubnov Rostyslav V. Svitlana O. Starovoitova Maryna V. Kryvtsova Larysa A. Ganova Tetyana V. Pavlyuk Melnykova Oleksandra A. Nataliia O. Tymoshok Iryna V. Dubova Tetiana V. Zhylikhovska Oksana V. Umarova Nina D. Aleinova Olha M. Vasyliuk Liudmyla M. Lazarenko popup.nrat_date 2026-03-19 Close