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Information × Registration Number 0226U003385, (0125U002847) , R & D reports Title Development of a catalyst for debenzylation of piperidine derivatives popup.stage_title Напрацювання каталізатора дебензилювання похідних піперидинів Head Shvets Oleksii V., Кандидат хімічних наук Registration Date 02-04-2026 Organization L. V. Pisarzhevskii Institute Of Physical Chemistry of The National Academy of Sciences of Ukraine popup.description1 Development of effective catalysts for the debenzylation of piperidine derivatives based on palladium-carbon composites to replace imported analogues popup.description2 During the reporting period, work was carried out to isolate palladium from spent catalysts (the total mass of spent catalysts provided by the customer was about 1 kg) and test the catalytic activity of representative samples based on palladium hydroxide deposited on coal of each batch in the debenzylation reaction of substituted piperidines. To recycle the spent Pd-containing catalyst, the coal mass was burned in a metal container covered with a lid (ethanol was used for ignition) until a non-combustible residue was obtained. The residue after combustion was boiled in a mixture (1/1) of concentrated hydrochloric acid and 30% hydrogen peroxide, cooled, filtered on a Schott filter. The resulting solution was evaporated on a vacuum rotary evaporator until the salt crystallization began. The mixture was removed from the rotor and left for crystallization. The precipitate that fell out was filtered off and dried on a filter, washed with hexane. The study of the catalytic activity of a representative sample of experimental batches of catalysts containing palladium nanoparticles in the debenzylation reaction of substituted piperazines, in particular N-benzylpiperazine, was carried out in a hydrogen atmosphere under conditions of elevated pressure and temperature. Aliquots of the reaction mixtures were analyzed using gas chromatography and mass spectrometry control. Testing of catalytic activity showed that each of the samples of the catalyst for the debenzylation of substituted piperidines provides a yield of the target product of at least 98%. Product Description popup.authors Ivan D. Kopa popup.nrat_date 2026-04-02 Close