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Information × Registration Number 0299U000481, 0196U001305 , R & D reports Title The causes and consequences of the memory T-cell excessive accumulation in ageing popup.stage_title Head Butenko G.M., Registration Date 05-12-2000 Organization Institute of Gerontology popup.description2 Object: lymphocytes 3 and 23 mo mice. Aim: to studythe memory T-cell functional peculiarity and consider the causes their excessive accumulation in ageing. Methods: flowcytometry; definition: splenocytes proliferative activity, antibody-producing cells number and their specificity. Scientific and practical results: established that after mice irradiation and bone marrow transplantation anamnastic response become inpossible. This fact evidence for memory cells functional damage or disappearence after irradiation. Novelty: at first was demonstrated the discrepancy between phenotypical markers and functional activity of memory cells in ageing. Effectivity: improvement of the scientific investigation quality. Fields of application: scientific investigations on gerontology, immunology, pathophysiology and radiobiology. Product Description popup.authors popup.nrat_date 2020-04-03 Close