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Information × Registration Number 0299U000487, 0196U001310 , R & D reports Title Age-related changes in gastric motor activity and secretory function (longitudinal study). popup.stage_title Head Chebotar'ov Dmytro Fedorovych, Registration Date 05-12-2000 Organization Institute of Gerontology popup.description2 Subjects: 82 persons aged between 30 and 79 years, who were investigated with the interval 5-10 years. The aim: to investigate the changes of gastric secretory and motor function with aging during longitudinal study. Methods: maximal gistamin test, mechanical balonokimography, endoscopy with biopsy, identification of HP infection with rapid urease test - De-Nol test. The results: From the moment of the first investigation gastroduodenal pathology appeared in 57 % of persons. In healthy subjects there was no significant changes in gastric acid output with aging. The decline in stimulated acid secretion with aging was related to a higher prevalence of chronic atrophic gastritis (CAG). The correlation between gastric motility and secretion was found to weaken with aging. Novelty: the age-related changes of gastric secretion and motor activity were investigated in the same persons during longitudinal study. It was shown the dependence of these changes on the presence of gastroduodenal pathology. Field s of application: clinical medicine, gerontology, gastroenterology Product Description popup.authors popup.nrat_date 2020-04-03 Close