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Information × Registration Number 0299U001904, 0196U010254 , R & D reports Title Synthesis and study of specific activity of the new compounds with thyrostatic and thyrostimulating action popup.stage_title Head Yaremenko Fedir Georgijovych, Registration Date 02-11-1999 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 New heterocyclic compounds. Search of active compounds that affect the function of thyroid gland among the derivatives of S-, N- and O-containing heterocycles. Chemical, toxicological, biochemical, histological, immunofermental. The new derivatives of partially hydrogenized thiazoles, imidazoles, pyrimidines, isobenzofuranones and their ensembles were synthesized. An in-depth study of the specific activity of seven compounds which have been detected in screening tests, at the experimental models of hypothyrosis was carried out. All the compounds were found to be of low toxicity and to have high antithyroid action. Two compounds were recommended for pre-clinical study. Pharmaceutical chemistry, endocrinology. Product Description popup.authors popup.nrat_date 2020-04-03 Close