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Information × Registration Number 0299U001962, 0197U002111 , R & D reports Title The relationship between amount of the stroma and differentiation of the cells gastric cancer popup.stage_title Head Vasylenko I.V., Registration Date 17-09-2001 Organization Donetsk state medical University named after M. Gorky popup.description2 Object of research: - 70 surgically resected gastric with cancer of the stomach. The aims of this study: - were to investigate the role of mucine and endocrine differentiation of cancer cells in formation of scirrhous stroma. Methods of research: - histhological, histhochemical, lectine-histhochemical, argirofili and argenthaphin cells by Grimelius and Masson methods/ Results: statistical analyses revealed correlation between amount of the stroma and histhological type of gastric cancer (r=0.40). Diffuse type of gastric cancer has shown a significantly higher amount of the stroma, than intestinal type. Wir defined that is the relationship between amount of the stroma gastric cancer and neutral mucin (r=0,42), endocrine differentiation of tumor cells (r=0,31). Detected divergence of tumor cells of diffuse and intestinal type in a association with lectines. In the cancer cells of diffuse type were observed more frequent connection with glucosamin-, sialil-specific lectines (HPA, SNA, WGA), whic h may reflected cell-matrix relationship. Novelty, efficiency: - this is the first report about simultaneous influence of mucin and endocrine differentiation on amount of the stroma of gastric cancer, more frequent connection with diffuse cancer cells the lectines, which related to the invasiveness. Sphere of use: pathology, oncomorphology, the diagnostic of gastric cancer. Product Description popup.authors popup.nrat_date 2020-04-02 Close