Search academic texts

Information × Registration Number 0299U001966, 0197U002096 , R & D reports Title Role of systemic and intratissue factors and mechanisms in individual stability of the miocard to stressory and ischemia damage popup.stage_title Head Umans'kyj Volodymyr Yakovych, Registration Date 17-09-2001 Organization State Medical University named after M. Gorky popup.description2 In the experiment on 63 rabbit-males of sort "Chinchillas" with stressory damages of miocard and 122 preparations all-out ischemizated insulated rat hearts with using of biochemical, biophysical, radioimmune methods of study is installed relationship between stability of the animals to the load exogenous sympathomimetics and contents in blood and miocard (source level) round-robin nucleotides (RN), prostanoids, products of peroxide oxidation of lipids (POL) and antioxidants. The way of forecasting stability of animals to the load exogenous sympathomimethics had designed and introduced. . In experiments with insulated myocard is evaluated influence of preliminary pharmacological modification POL, metabolic cascade an arachidonic acid and exchange RN on adrenoreactivity and degree of damaging insulated of miocard under its perfusion of izadrin. This has allowed to motivate perspective directions of method development to pharmacological correction adrenoreactivity and stability of miocard to cathecho lamine (stressory) to damages. Scope of using: research laboratories, chairs of pathophysiology. Product Description popup.authors popup.nrat_date 2020-04-02 Close