Search academic texts

Information × Registration Number 0301U002412, 0100U003323 , R & D reports Title Role of heme and hemoproteins in regulation of metabolic adaptation system under oxidative stress. popup.stage_title Вплив спроможності триптофан -2,3-діоксигенази зв'язувати гем на активність ключових ферментів метаболізму гему печінки. вміст та активність гемопротеїнів та окисний стан ліпопротеїнів печінки і сироватки крові за умов оксидативного стресу. Head Kaliman P.A., Registration Date 06-05-2001 Organization Kharkov National University named after V.N.Karazin popup.description2 Subject of this investigation was to study of heme and lipid metabolism ,the antioxidant enzymes activities in rat liver and blood serum under the oxidative stress conditions. The aim of this study was investigate the role of heme and homoproteins in the regilation of adaptation system under the oxidative stress.The role of cytosole heme-binding protein ,tryptophan -2,3-dioxygenase in prevention of damaging action of heavy metal ions on intracellular hemoproteins and in reneval prooxidant -antioxidant equilibrium in rat liver and blood serum after injection of heavy metals salts. The Wistar rats were used in the work. The results obtained show that the increasing of heme-binding ability of tryptophan-2,3- dioxygenase by L-tryptophan stabilization provides a rapid binding and degradation free heme ,which accumilates in liver after HgCl2 administration there fore the cytocrome P450 level is preserved.Co-administration of L-.truptophan and CoCl 2 doesn't lead to the recovery of prooxidant -antioxidant equilibrium in liver cells and to preservation of cytochrome P450 level. Product Description popup.authors popup.nrat_date 2020-04-02 Close