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Information × Registration Number 0302U001285, 0100U002770 , R & D reports Title To study the significance oxidative-stress component of radiation impact upon the state of the central nervous system popup.stage_title Поглиблені дослідження оцінки закономірностей модифікації наслідків радіаційного впливу на стан центральної нервової системи антиоксидантними засобами Head Rudnyev Mykhajlo Ivanovych, Registration Date 14-02-2002 Organization Research Centre for Radiation Medicine popup.description2 Object: combined exposure to ionizing radiation and antioxidants upon the higher nervous activity. Goal: to assess regularities of different doses of ionizing radiation biological effects modification by antioxidants according to the data on functional, biochemical, and morphological indices of the central nervous system state. Techniques: behavioral, polarography, photocalorimetric, spectrophotometric, electron microscopy, statistical. According to the data of neurophysiological studies, contribution of the oxidative-stress component to the changes of the CNS functional state that are caused by the exposure to radiation (at the doses of 0.05, 0.5, and 5 Gy) and emotional-pain stress are prevailing; to make this conclusion more precise, studies with different doses of antioxidant means are necessary. Free radical processes activation in brain after exposure at 0.1 to 5 Gy is nonlinear; one month after exposure, its maximum corresponds to 0.5 Gy. The dose of 5 Gy inhibits tissue respiration, reduces cat alase activity. Beta-carotene and alfa-tocopherol essentially correct these changes. At these dose, significant morpho-functional disturbances are observed in the neurons of brain cortex and neurosecretory cells of neuroendocrine system. Selenium preparations facilitate restoring processes in the studies structures and, especially, in the secretory cells of the neuroendocrine system. Product Description popup.authors popup.nrat_date 2020-04-02 Close