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Information × Registration Number 0302U001593, 0100U003334 , R & D reports Title Investigation of the hydration and the biological active substances influence on macromolecules and cels in the ionizing radiation conditions popup.stage_title Спектроскопічне дослідження механізму взаємодії біологічно активних речовин с ДНК. Побудова динамічної моделі впливу іон-гідратного оточення на конформаційний стан ДНК. Розробка математичних моделей Head Malyeyev V.,Gatash S., Registration Date 28-03-2002 Organization Kharkov National University named after V.N.Karazin popup.description2 The purpose of work - study on mechanisms of interaction of biologically active substances with DNA, proteins, biological membranes and cells and influence of an irradiation on their structure and functions. At perfomance of work the received such basic results: The hydration of the various structural forms of polyribocytidical acid and its components by a Monte Carlo method was studied. The influence of protonation on hydration of cytosine associates and the role of water in the stabilization of helical structure of polyribocytidilic acid is founded. The cooperative character of interaction of anthracycline antibiotic daunomycin with polynucleotides of various base compositions and secondary structures in solutions with low ionic strength is established. The constants, number of binding sites and cooperativity parameters of interaction are determined. The temperature dependencies in range of 0-70 C of the real and imaginary parts of permittivity of blood plasma and serum irradiated with doses 10-80 Gr have been obtained. The increase of fat-soluble vitamins level in all organs in a month after single irradiation was founded. The most activation of peroxide of lipids of spleen and brain is concerned on adaptation of organism to action of subletal dose of radiation. The results of this work can be used for development of anticancer, antioxydant and radioprotective agents. Product Description popup.authors popup.nrat_date 2020-04-02 Close