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Information × Registration Number 0302U001750, 0100U003457 , R & D reports Title To work functions of glutathione at of the patogenesis cataract and degeneration of the macula and metabolic status popup.stage_title Визначити ензиматичну активність метаболічних систем глутатіону в крові хворих і в експерименті. Head Leus Mykola Fedorovych, Registration Date 17-04-2002 Organization The Filatov Research Institute of Diseases and Tissue Therapy popup.description2 Finding out the role of disturbances of glutathione metabolic functions in the pathogenesis of senile cataract and macula degeneration we decided to ground the expediency of correction of glutathione metabolic state. Chinchilla rabbits were used for modelling of light cataract. The animals received acetoaminophen per os for stimulation of glutathione-S-transferase activity. It was revealed that combined modelling of light cataract and introduction of acetoaminophen, as a xenobiotic, considerably increases the rate of development of pathological changes in the eye and causes functional disturbances og glutathione system in rabbit retina and lens. Disturbance of the activities of the glutathione dependent enzymes in blood was detected in patients with senile cataract and macular degenerati5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close