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Information × Registration Number 0303U003232, 0101U001458 , R & D reports Title Mechanisms study of metabolic disturbances under combined exposure to low doses of external and internal ionizing irradiation. popup.stage_title Дослідити процеси метаболічних порушень за умов впливу на організм дослідних тварин малих доз (1,85 МБк/кг, 1835 МБк/кг) внутрішнього іонізуючого опромінення (137Cs) Head Rudnev M.I., Registration Date 05-03-2003 Organization Research Centre for Radiation Medicine popup.description2 Object of study - laboratory rats, their organs, tissues, tissue homogenates, cell suspension. The aim - to study peculiarities of metabolic disturbances based on the data of the oxidative phosphorilation, lipid peroxydation processes, of enzymes-antioxidants activities, of apoptosis, and of hematological data under exposure to low doses internal ionizing irradiation. Methods of the study - biochemical, polarographic, cytofluorographic, hematological. The intraduction of peroral radioisotops 137 Cs (1,85 MBk/kg; 18,5 MBk/kg) leades to disbalance in methabolism of investigational animals. The common exhange of substances encreases, which fined in increasing of contain blood serum tireoid hormones and intencification of processes oxidation phosphorilation in tissues. The moderate energetic deficit was obseved. The functional activity of marrow's blood formation was increasing. The common quantaties of limphosites, leycosites, neitrophil granulosites were decreased. The process of peroxidation essentially increased and MDA quantaties in tissues increased. The common disbalance was correlated in antioxidant sistem. Exchanges of activities of enzimes - antioxidantes were organospecific, different directed and dependent from incorporaten radioactivity and termin after irradiation. Was noted acceleration of wear of cells in irradiational organizm, which were eliminated by apoptotic way. On the foil of common disbalance were observed several significantes of adaptive processes, procceded in blood and tissues. Product Description popup.authors popup.nrat_date 2020-04-02 Close