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Information × Registration Number 0303U003371, 0102U003445 , R & D reports Title Development of optimal criteria for evaluation of pharmacological activity of androgen receptor blockers popup.stage_title Розробка оптимальних критеріїв оцінки фармакологічної активності блокаторів андрогенних рецепторів Head Reznikov O.G.., Registration Date 14-04-2003 Organization V.P.Komisarenko Institute of Endoсrinology and Metabolism popup.description2 Object: reproductive system organs and blood of male and female rats. Aim of the work: Study of the most informative crateria for evaluation of pharmacological action of antiandrogens and development of algorythm for search and investigation of antiandrogen preparations. Methods and apparatus: physiological, biochemical, morphological; spectrophotometer, (- and (-spectrometers, microscope, low temperature refrigerator, computer. Theoretical and practical results: the most informative criteria for evaluation of specific activity of non-steroidal antiandrogens and optimal duration for its study in males and androgenized females have been found. The dose dependence of the specific antiandrogen effect in females with experimental hyperandrogenism has been revealed. Field of application: endocrinology, gynecology, andrology. Product Description popup.authors popup.nrat_date 2020-04-02 Close