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Information × Registration Number 0304U002089, 0102U002294 , R & D reports Title Elaboration and improvement of radical safing surgical treatment of long bone tumors popup.stage_title Теоретично-експериментальна розробка радикально-зберігаючих втручань при пухлинах довгих кісток Head Korzh A.A., Registration Date 29-01-2004 Organization Ukrainian Academy of Medical Sciеnces Sytenko Institute of Spine and Joints Pathology popup.description2 For the abovemention period we analyzed the results of already known modern curative methods for the long bone tumors applied in the orthopedic practice now. Patent and informational investigation regarding the use of variable materials for the substitution of bone defects and their possible filling by cytostatics. Different methods of applying multi-level functional covers on the metal implants widely used in modern oncoorthopeadics were studied. The immunity condition and proteolytic ferment activity in patients with bone tumors depending on the scheme of complex treatment was analyzed. After searching the potential of cytostatic medicines in surgical treatment of bone tumors in the scientific literature the experiment on possible filling of variable ceramic implants by anti-tumor medicines and kinetics of their penetration in tissues and achieving curative concentration in the area of neoplasm was conducted in vivo and in vitro by method radioactive indicators. The morphology of bone tissue osteoreparation under condition of using implants on the basis of hydroxylapatite with cyclophosphan and methatrexate was also investigate Product Description popup.authors popup.nrat_date 2020-04-02 Close