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Information × Registration Number 0304U004108, 0103U004273 , R & D reports Title Investigation of the environmental geropromoting factors influence in the functional state of membrane redox-systems during ontogenesis popup.stage_title Дослідження ролі змін фуекціонального стану біомембран у процесі прискорення старіння Head Padalko V.; Lemeshko V., Registration Date 20-03-2004 Organization Kharkov National University named after V.N.Karazin popup.description2 Object of research - fly Drosophila melanogaster, yeast Saccharomyces cerevisiae. The purpose of work - research of mechanisms of participation of the factors of environment in an induction of premature aging at a level of structurally and functional changes of mitochondrial and microsomal membranes and development of perspective ways and means of delay of premature aging and influence on speed of aging in general. Methods of researches - differential spectrophotometry, fluorescent microscopy, biochemical analysis of enzyme activity and metabolite contents, accounts and construction of a survival curves . Is established, that the insects, which received uncoupling agent - 2,4-dinitrophenol, had the large average life expectancy. Is shown, that the entering into a food mix of the nitric oxide donor - sodium nitroprusside, essentially reduces life expectancy of insects. The received preliminary results concerning speed of mitochondrial respiration, alcohol dehydrogenase activity and stability to starvation testify that 2,4-dinitrophenol and sodium nitroprusside at joint introduction it is essential correct action each other on insects. Most brightly it was showed at examining an integrated parameter of a condition of organism as a whole, which the life expectancy is. Product Description popup.authors popup.nrat_date 2020-04-02 Close