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Information × Registration Number 0305U001599, 0104U006264 , R & D reports Title Research of influence of excipients on bioavailability of drugs to determinate the possibility of excipient interchange in tablet drug forms. popup.stage_title Дослідження впливу допоміжних фармацевтичних речовин (ДФР) на біодоступність лікарських засобів з метою визначення можливості взаємозаміни ДФР у готових таблетованих лікарських формах. Head Georgievsky Victor Petrovich, Registration Date 23-03-2005 Organization State scientific center of drug means popup.description2 With the purpose of the determination of the possibility of pharmaceutical excipients interchangeability in drug products, the pharmacokinetics studies of excipients effect on the bioavailability of tablets with different drug substances have been carried out. It was concluded that amiodarone (the substance with lipophilic properties and prolonged circulation in blood) bioavailability was not depended on shape-building and wetting agents composition. The bioavailability of ibuprofen (lipophilic) and metoprolol tartrate (hydrophilic), whose elimination rate is high, was decreased with some combinations of shape-building and wetting agents. Change of shape-building agent has no effect on substances bioavailability essentially. The absence of single line of wetting agents effect on substances bioavailability, first of all for substances with rapid elimination, was shown.The comparative pharmacokinetics studies of production prototypes of atenolol tablets with excipients of different compositions demonstrate that they differ substantially between themselves in bioavailability and are not pharmacokinetic equivalent to their foreign analogue, Product Description popup.authors popup.nrat_date 2020-04-02 Close