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Information × Registration Number 0305U001765, 0103U000883 , R & D reports Title Investigation of vitamines B1,B6 and their derivatives on synaptic transmission in warm-bloodedanimal organisms muscles popup.stage_title Дослідження впливу на синаптичну передачу в м'язах теплокровних тваринних організмів вітамінів В1, В6 та їх похідних Head Romanenko Olexander V., Registration Date 21-04-2005 Organization National Medical University popup.description2 The vitamin B1 shares in quantum secretion of a neurotransmitter of acetylcholin from the nervous terminals in a skeletal muscle of mammalian organism. The deficit of vitamin B1 provoces depression of evoked acetylcholin quantum secretion from the nervous terminals and decrease of postsynaptic membrane sensivity to this mediator, that gives the decrease of efficacy of synaptic transmission in a skeletal muscle of the mouse. In smooth muscles of a colon of the human pyridoxal-5'-phosphate (PP) (1 10-4 M) causes change of inhibiting synaptic potentials (ISP), depression a post -ISP depolarization of smooth muscle cells. Isoniazid (1 10-3 M) decrease PP (1 10-4 M) influence on synaptic transmission in a circular layer of smooth muscles of a colon of the human Product Description popup.authors popup.nrat_date 2020-04-02 Close