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Information × Registration Number 0305U005797, 0101U009227 , R & D reports Title To develope the methods of synthesis of the new physiological active substances, derivatives of condensed, noncondensed and macroheterocyclic azolidones, to study their physical and chemical properties and biological action, to research the different kinds of Carpathian flora plants to get the potential drugs, to develop technology of medicine forms of new composition and to work out the modern methodological approaches of their analysis popup.stage_title Розробити методики синтезу нових фізіологічно-активних речовин, похідних конденсованих, неконденсованих і макрогетероциклічних азолідонів, вивчити їх фізико-хімічні властивості та біологічну дію, дослідити різні види рослин прикарпатської флори з метою одержання потенційних лікарських засобів, розробити технології лікарських форм нових складів та опрацювати сучасні методики їх аналізу Head Zimenkovsky B. S., Registration Date 27-12-2005 Organization Danylo Halytsky Lviv National Medical University popup.description2 The objects of investigation are newly synthesized and extracted from plants sources new bio-logical active substances and also substances which can be found in biological objects and can be used in medicine. Using a purposeful synthesis about 300 new derivatives heterocyclic compounds, 2,4-dioxoazolidin-3-carbonic acids, arylamides 5-arylidenrhodanin-3-dicarbonic acids and series of combinatorial library of heterocycles were synthesized. Pharmacological prescreening of synthe-sized compounds was carried out. The anticancer, antimicrobial, anti-inflammatory and antitubercu-lar activities of some obtained compounds were established by means of biological screening. The contant of biological active substances which are present in such plants as Achilles L., Melilotus Mill., Artemisia L., Pastinaca L., Archagelica Hoffm., Laserpitium L., Cotinus Mill., Bidens L. was studied. Extracted phytosubstances have interferoninductive, antimicrobial, anti-inflammatory, cytoprotective and photoprotective action. Thecomposition and technology for new complex drugs with anti-inflammatory, antifungal, photosensibility action and also homeopathic drugs for treatment of pathology of coronary blood circulation were worked out. The structure of the synthesized compounds has been confirmed by physico-chemical methods (UV-, IR-spectra), their purity and identification was controlled by the polarography, photocolory-metry and chromatography. The methodological approaches of quantity analysis of compounds in a substances and drugs were developed. Product Description popup.authors popup.nrat_date 2020-04-02 Close