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Information × Registration Number 0306U001284, 0103U001408 , R & D reports Title To determine a role of blood genetic systems and some molecular-genetic markers of tumoral clones in a complex estimation of efficiency of a transplantation stem hemopoietic cells at patients leukemias, lymphomas and solid tumours popup.stage_title Вивчення фенотипової асоційованості маркерів різних генетичних систем крові і молекулярно-генетичних порушень з формуванням посттрансплантаційних ускладнень і залишкової резидуальної хвороби у хворих на лейкемії, лімфоми та солідні пухлини у віддалений післятрансплантаційний період Head Bebeshko Vladimir Grigorovich, Доктор медичних наук Registration Date 20-02-2006 Organization Research Centre for Radiation Medicine popup.description2 Object: children and adults with leukemias, lymphomas and solid tumours. The purpose: to determine character assocation of markers of various genetic systems of a blood and molecular-genetic infringements with formation aftertransplantation complications and the minimal residual diseases at patients with leukemias, lymphomas and solid tumours in remote the aftertransplantation period. Methods: clinical, hematological,immunogenetic, immunological, cytogenetic and molecular-genetic. Results of treatment of 152 patients with oncogematological pathology are analysed, from which 59 transplantation SCPB was carried out. It determined, that current and efficiency of treatment of diseases are in interrelation with the certain molecular-genetic infringements,immunogenetic markers of a blood and dermatoglific characteristics. The increased concentration of a phenotype O (I) at patients with MM and dependence of efficiency of application of VAD therapy at patients from a group accessory is revealed. A carriage specifications: HLA-Cw*06; DQB1*0501; DQB1*0601 in HLA- genotype of patients with MM is the factor of genetic predisposition to the MM. The positive answer to a transplantation is associated with a carriage of alleles HLA-Cw*06 and HLA-DQ A 1*0101. Product Description popup.authors popup.nrat_date 2020-04-02 Close