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Information × Registration Number 0306U001855, 0101U003300 , R & D reports Title The mechanisms function Detoxication system's of organism and erythropoesis popup.stage_title Механізми регуляції детоксикаційної функції організму та еритропоезу Head Filimonov V.I., Registration Date 29-06-2006 Organization Zaporozhye State Medical Univercity, department of tuderculоsis popup.description2 For the first time kinetics of erythropoiesis in conditions of its stimulation and depression and the state of oxidant homeostasis in kidney tissues in such processes in rats was fully studied. Data about direct effect of oxidant homeostasis on kidney tissues and on erythropoiesis regulating mechanism are obtained. It was shown in experiments in vivo and in vitro that serotonin in concentrations close to physiological ones is antioxidant and thus takes part in erythropoiesis regulation. It was stated that concentration of blood and kidney serotonin depends on filling of spleen with blood. It was proved that by means of depositing function of spleen interaction between systems of blood circulation and hematosis is provided. Kinetics of oxidant homeostasis and functional state of heart tissue in first minutes of total loss of blood and replacement of blood with oxygenic Ringer-Lock solution with antioxidants rumasol and thiotriazoline was studied.Antioxidative role of melatonin in antioxidant protectionof hepatocytes was stated.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close