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Information × Registration Number 0306U003616, 0101U005083 , R & D reports Title Study of structure and properties of carbohydrates and compounds containing carbohydrates and biopolymers popup.stage_title Вивчення будови і властивостей вуглеводів та вуглеводомістячих сполук і біополімерів Head Chirva Vasyl' Yakovych, Registration Date 05-06-2006 Organization National Taurida V. Vernadsky University popup.description2 Synthesis of new glycosyded derivatives of muramoildipeptides with aglycones of the various nature is carried out, their imunostimulated and antineoplastic action is studied. Synthesis of bis-O-(N-acetylglucosaminil) di- and olygomethylene - initial products for reception of double analogues of MDP is carried out. The rests of synthetic analogues containing as phenolic components natural coumarines and chromones are synthesized new ariluronates. Reactions of glycosilating of heterocycles at presence of crown-ethers are studied. The basic laws of process glycosilating are established. The basic approaches to reception on the basis of spacered glycosides N-acetylglycosamine of various amydes are fulfilled. It is shown, that 2-alcoxyglycosiloxazolines unlike corresponding 2-alkilglycooxazolines are highly active glycosilated agents, capable to cooperate with spirits in the basic environments. The way of synthesis remote b-D-mannoseaminides is developed. Synthesis of lactame of normuramic acid as a result of intramolecular O-alkilating in molecule N-bromeacetyl derivative D-glycosamine is carried out. The structure of triterpene glycosides from plants of Araliaceae is investigated: Fatsia japonica, Brassaia actinophylla, Dizygotheca elegantissima, Pseudopanax crassifolius (Sol. ex A. Cunn.) C. Koch and its versions P. crassifolius var. trifoliatus Kirk, Aralia elata. A number of new triterpene glycosides of gypsogenine, hederagenine, oleanolic and ehinocystic acids is allocated. Their biological activity is investigated. The technique of synthesis of benzimidazole and its derivatives at presence of the metaboric acid is developed, allowing to receive target products with higher outputs. Product Description popup.authors popup.nrat_date 2020-04-02 Close