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Information × Registration Number 0307U009071, 0106U012514 , R & D reports Title The develop the treatment methods of prognostically unfavorable soft tissue malignant neoplasms in children popup.stage_title Розробити програми комплексного лікування злоякісних новоутворень м’яких тканин у дітей з урахуванням прогностичних факторів клінічного перебігу захворювання Head Klymnuk G.I., Registration Date 25-12-2007 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Object of study: 13 children with prognostically unfavorable malignancies of soft tissues (MST), 10 samples of tissues of the above said tumors, 21 samples of peripheral blood and 10 – a bone marrow. Objective: to improve the results of therapy of children with unfavorable malignancies of soft tissues (MST) by use of new methods for definition of groups of risk of patients using new programs of intensive polychemotherapy (PCT). Methods: clinical, angiographic, radiation, ultrasonic, molecular-and-genetic, immunological, immunocytochemical, statistical. Equipment: РАСScan" Весton Dikenson ", USA, 7300 Rеа1-Time РСR System "Applied Biosystems " USA, ATLHDI-5000 "Рhilips" USA, " Тоshibа Аsteon Super 4 ", Japan, "Stenoscop 9000 ", USA. Results: PCT with use of topotekan the direct positive result was received in 5 of 7 patients, remission was achieved in 30,8 % of patients with MST of high risk. Maintenance of hemopoiesis with stem cells of peripheral blood (11 patients) twice reduces duration of leucopenia and thrombocytopenia of 4 grade, decreases frequency of complications connected with myelosuppression. Angiographic symptoms of change of blood flow in tumor in PCT correlate with findings of Doppler-US examination. Definition of genetic markers РАХ by 3/7 by the method of polymerase chain reaction improves stratification of patients (additionally micrometastasises to bone marrow in 5 of 10 children with MST were revealed). On findings of this study in 24 children with MST suppression of cellular and humoral immunity and function of thymus was revealed. Disorders amplify after PCT and achievements of remission. For the period 1995-2005 in Ukraine there is a tendency of incidence of MST among children with stable mortality rate. Field of application - Pediatric oncology. Product Description popup.authors popup.nrat_date 2020-04-02 Close