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Registration Number

0308U001127, 0107U000922 , R & D reports

Title

Efficacy estimation of curative-prophylactic tools directed on correction of clinical/metabolic manifestations of syndromes of leptinresistance and insulinresistance in ChNPP accident survivors, their descendants, with application in healthcare practice

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Розробка протоколу дослідження. Здійснення відбору патогенетично обґрунтованих лікарських засобів та їх комбінацій, спрямованих на корекцію клініко-метаболічних порушень у осіб, які постраждали внаслідок аварії на ЧАЕС та їх нащадків при синдромах лептино- та інсулінорезистентності. Розпочати апробацію визначених лікарських засобів і відпрацювання схем їх призначення на пацієнтах в залежності від характеру клініко-метаболічних розладів.

Head

Kovalenko A.N.,

Registration Date

21-01-2008

Organization

Research Centre for Radiation Medicine

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Study subject - ChNPP survivors i.e. emergency workers of 1986 period and residents of contaminated territories having leptinresistance and insulinresistance syndromes, aged 14-45 years at the time of accident (297 persons), children born in 1987-1993 (142 persons); 439 persons in total. Study objective is the efficacy estimation of curative-prophylactic tools directed on correction of clinical/metabolic manifestations of syndromes of leptinresistance and insulinresistance in ChNPP accident survivors. Study methods - clinical, antropometric, biochemical & hormonal assays, instrumental approaches and statistics. As a results the specialized protocols for revelation and survey of patients having leptinresistance and insulinresistance syndromes ware designed. Pathogenetically substantiated pharmacological tools were selected for the correction of clinical/metabolic manifestations of syndromes of leptinresistance and insulinresistance. Pathogenetic therapy tools application was launched, in particular focused on their efficacy assay in clinical/metabolic manifestations of syndromes of leptinresistance and insulinresistance correction. It has occurred that IR & LR syndromes arise in ChNPP accident survivors at lower body mass excess levels compared to entire population. Lipid metabolic abnormalities at that correspond to moderate or severe vascular damage according to the mainly atherogenic type of dyslipidemic phenotypes. In children of the ChNPP accident survivors having body mass excess hereditary features of IR presentation are peculiar, at that hyperinsulinemia severity does not depend on obesity grade both as glucose intolerance does. Metabolic correction at that is possible through lifestyle and eating behavior modification. Metformin medications are indicated in severe obesity cases. The full-scaled picture of metabolic syndrome X in ChNPP accident survivors requires complex approach with application of insulinsensitizers, hypotensive and hypolipidemic agents. Insulin preparations are required in severedisorders of carbohydrate metabolism. Final definitive decision on optimal therapy schemes in IR & LR syndromes in ChNPP accident survivors requires the entire study scope completion within forthcoming two years.

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2020-04-02