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Information × Registration Number 0308U001130, 0107U000925 , R & D reports Title Treatment of the radiation-associated acute leukemia with use of stem hemopoietic cells procedure of a various origin at survives after Chernobyl Accident in view of molecular-genetic features of pathological process popup.stage_title Визначення молекулярно-генетичних характеристик субстратних клітин при гострій лейкемії в осіб, опромінених внаслідок аваріїї на ЧАЕС, і оцінка ефективності методу магнетичної селекції трансплантату стовбурових гемопоетичних клітин для виділення CD34+ фракції Head Klimenko Sergey Viktorovich., Registration Date 21-01-2008 Organization Research Centre for Radiation Medicine popup.description2 Object: AML, ALL at survives after Chernobyl Accident, inhabitants it is radioactive the polluted territories and persons without the radiating anamnesis. The purpose: To prove use of procedure of transplantation stem hemopoietic cells received from different sources, for treatment of patients by the radioactive-associated leukaemia, survives after Chernobyl Accident, on the basis of studying molecular-genetic features of pathological process and opportunities of processing of a cellular transplant. Methods: morphological, immunological, molecular-genetic, cytogenetic, immunogenetic, cultural, statistical. It is proved, that patients with radiation-associated AL are characterized by shorter general survival rate. Mutations of gene FLT3 do not play an essential role in leukemogenezis at development AML in the survives after Chernobyl Accident. Quantitative and structural infringements of karyotype at patients with AL are determined. At patients with ALL authentic decrease in frequency of phenotype AB (IV) is revealed. Presence at a HLA-genotype of the person HLA-B*35; HLA-B*51; HLA-Cw *07 and HLA-DRB1*11 it is necessary to count factors of genetic predisposition to AL. Efficiency kolonieforming cells of BM and the PB of patients AL is appreciated. The estimation of efficiency of a magnetic selection of transplant SHC is given. Product Description popup.authors popup.nrat_date 2020-04-02 Close