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Information × Registration Number 0308U001354, 0103U002362 , R & D reports Title Clinical and pathogenetical features of inflammatory, metabolic and vascular encephalopathia at Laym-borreliosis, Leptospirosis and Viral Hepatitis popup.stage_title Клініко-патогенетичні особливості запальних, метаболічних, судинних енцефалопатій при Лайм-бореліозі, лептоспірозі та вірусних гепатитах Head Zinchuk O.M., Registration Date 30-01-2008 Organization Danylo Halytsky Lviv National Medical University popup.description2 Development predictors of hepatic encephalopathy on an example 179 patients with leptospirosis, 112 patients with Lyme - borreliosis, 116 patients with acute viral hepatitis B and/or C and 118 patients with chronic hepatitis B and/or С have been determined in the work. Epidemiological regularities of 112 cases of Lyme- borreliosis have been generalized. It is ascertained that maintenance of intratekal antibodies in liquor at neuroborreliosis considerably prevails their concentration in the serum. It is set that 70% of patients with chronic viral hepatitis have all symptoms of encephalopathy, mostly in a latent form. Efficiency of treatment of encephalopathy is proved along with used of method of ozonetherapy. The new method of treatment of extrahepatic manifestations of chronic hepatitis B and С is offered with the usage of vaccination with autolymphocytes. Determination of sensitizing of organism is conducted according to the synthesis of cages factor of necrosis. It is determined that at chronic hepatitis B the highest level of sensitizing to antigens of HBeAg, HBcAg is observed in patients with the integrative form of infectious process. It is shown that at Lyme-borreliosis the indexes of sensitivity are considerably higher for patients with the nonerythemic forms of illness and at presence of dissemination signs. It is tested and proved the efficiency of new noninvasive method of estimation of morphological changes in liver at chronic hepatitis. The research of cerebral hemodynamics is conducted by means of method of transcranial doplerography, processes of oxide of nitrogen exchange and level of endogenous intoxication for patients with initial hepatic encephalopathy, the charts of monitoring of severe forms of viral hepatitis and prevention of unfavourable consequences are developed. For accumulation and analysis of clinic-laboratory data of patients with Lyme-borreliosis programmatic modules of "BORRELIOSIS" and "LEPTOSPIROSIS" are created for a computer database called "Electronic archive". Product Description popup.authors popup.nrat_date 2020-04-02 Close