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Information × Registration Number 0308U007647, 0107U000918 , R & D reports Title Ellaboration of strategy of risk-adaptation therapy for patients with chronic lymphoproliferative diseases with usage of hemopoietic stem cells transplantation popup.stage_title Вивчити фенотипову асоційованість маркерів різних генетичних систем крові з маркерами молекулярно-генетичних, цитогенетичних і імунологічних порушень в співставленні з особливостями перебігу захворювання на різних етапах лікування хворих із застосуванням трансплантації гемопоетичних стовбурових клітин. Визначити прогностичне значення досліджених маркерів генодіагностики. Head Minchenko Zanna Nikolayevna, Доктор біологічних наук Registration Date 23-12-2008 Organization State Institution "Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine" popup.description2 Object: patients with CLL, MM, An' Hodgkin malignant lymphoma, Hodgkin lymphoma. The purpose: to carry out the analysis association markers of different genetic systems of blood with markers molecular-genetic, cytogenetic and immunologic infringements and features of current chronic lymphoprolipherative diseases on different treatment patients with use of transplantation hemopoietic stem cells and to determine them prognostic value. Methods: hematological, immunogenetic, immunological, cytogenetic, dermatoglyphic, cultural and molecular-genetic. The data on interrelation clinic-hematologic features of current of disease of patients CLL with genetic markers of blood are received. The positive association of disease with alleles HLA-DRB1*11, HLA-Cw*07, HLA-В*40 and allel HLA-В*35 is established. At patients CLL in a stage of a clinical progression of disease and high risk of development refracternestly to therapy it is determined high a level of spontaneous secretion immunocompitation by cells IL-1 ? andlow level IL-2 and IFN-? in whey of blood. Presence at a phenotype sick CLL determined dermatoglyphic characteristics and HLA-specifications (HLA-А*03, HLA-В*40, HLA-DRB1*11) is connected to the adverse forecast of current of disease. Product Description popup.authors popup.nrat_date 2020-04-02 Close