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Information × Registration Number 0308U007654, 0107U000925 , R & D reports Title Treatment of the radiation-associated acute leukemia with use of stem hemopoietic cells procedure of a various origin at survives after Chernobyl Accident in view of molecular-genetic features of pathological process popup.stage_title Вивчення цитогенетичних особливостей субстратних клітин, імуногенетичного профілю у хворих на радіаційно-асоційовану гостру лейкемію та визначення доцільності застосування для їх лікування стовбурових гемопоетичних клітин, отриманих з різних джерел Head Klimenko Sergey Viktorovich, Registration Date 23-12-2008 Organization Research Centre for Radiation Medicine popup.description2 Object: AML, ALL at survives after Chernobyl Accident, inhabitants it is radioactive the polluted territories and persons without the radiating anamnesis. The purpose: to determine expediency of use for treatment sick radiation-associated acute leukemia stem hemopoietic cells received from different sources on the basis of studying cytogenetic of features substract cells, immunogenetic structure. Methods: morphological, molecular-genetic, cytogenetic, immunogenetic, cultural and statistical. Comparison of features caryotype and molecular-cytogenetic characteristics of patients AL, undergone to influence radiation, and patient's spontaneous leukemia's not revealed authentic distinctions in quantity and quality of infringements. At patients the reduced concentration of phenotype AB (IV) is observed is not dependent on presence or absence of influence ionization irradiations. It is established, that variants of current of leukemia's are caused by presence at a phenotype sick determined dermatoglyphic parameters. Cells of a bone marrow of patients spontaneous and radiation-associated AL are capable to grow ripe in culture under influence kolonieforming the factor and to form granulomonocytar colonies for stem cells residual normal hemopoiesis. Product Description popup.authors popup.nrat_date 2020-04-02 Close