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Information × Registration Number 0308U008319, 0104U010501 , R & D reports Title Immune-genetic, epidemiologic, pharmacogenetic and clinical microbiology aspects of interactions between host and pathogen system in the course of tuberculosis infection in rising tuberculosis incidence rates popup.stage_title Вивчити фактори ризику трансмісії ме-дикаментозно-стійких збудників туберку-льозу та роль ВІЛ-інфекції в цьому процесі. Head Bazhora Yuri, Доктор медичних наук Registration Date 02-12-2008 Organization Odessa state medical university popup.description2 Dynamics of drug resistant strains circulation in Odessa oblast and risk factors for drug-resistant and highly virulent strains transmission were studied. The molecular-genetic method of determination of resistance to isoniazid, related to the mutation 315 codon of gene of katG is approved. Frequency of mutation of gene of katG is studied at isoniazid-resistance (87.0%). It is shown that the mutation of gene of katG is more frequent among Beijing family starins. The method of rifampicin-resistance detection by PCR is mastered on the presence of mutation in 516, 526 and 531 codon of rpoВ gene. Frequency of the these mutations in the gene of rpoВ was 45.1% in rifampicin-resistant cultures. From them 4.8% was the mutations of codon 516, 14.3% - codona 526, 80.9% - codon 531. It is shown that on frequency of mutations in the rpoВ gene influence history of antituberculosis treatment, and history of imprisonment. Product Description popup.authors popup.nrat_date 2020-04-02 Close