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Information × Registration Number 0309U000102, 0108U000195 , R & D reports Title To study the effect chemoradiomodifiers and interferon on the efficacy of radiotherapy of patients with locally advanced cancer of uterine cervix popup.stage_title Вивчення можливості використання молекулярно-генетичних ознак агресивності пухлинного процесу для оцінки ефективності променевого лікування із застосуванням хіміорадіомодифікаторів та інтерферону при лікуванні хворих на місцево поширені форми раку шийки матки Head Ivankova V.S., Registration Date 26-01-2009 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Object of study – patients with advanced forms of cervical cancer. Objective - to increase the efficiency of radiotherapy of patients with advanced cervical cancer (ACC) by use of chemoradiomodifiers and interferons. Methods and instruments: clinical, laboratory, radiological, ultrasonic, dosimetric. ROCUS, simulator of a session of radiation - "SimViw" 3000 (Siemens, Germany), AGAT - VU, US-unit "Aloca" FLEXUS, universal dosimeter PTW Freiburg "Unidose E centrifuge "ОPN-3 " with revo 2000 g, flow cytofluorimeter " FAScan " (BECTON DICKSON, USA) № 82582, 1991. Results: It has been studied the dependence of sensitivity of advanced cervical carcinomas to cytotoxic effect on the content and ploidy of DNA tumor genomes and parameters of proliferative activity of tumors, definited by DNA flow cytofluorimetry. The obtained data correlate with findings of clinical and instrument examination of ACC patients. The developed methods of conservative treatment of ACC patients which anticipate simultaneous use of combination radiotherapy, cytostatics at radiomodifying doses and interferon. The complex examination and radiation treatment on a background of chemoradiomodifiers and interferon of 40 ACC has been performed. The obtained preliminary results evidence on the efficacy and unavailability of excessive toxicity of the developed methods and there is no need for the correction of the developed methods of treatment. The investigation of parameters DNA-status of tumor clones and their proliferative activity opens prospects for individual approaches to CRT of ACC patients. The dynamics of the contents and ploidy of cell DNA can be additional criterion of the efficiency of treatment. Field of use: specialized oncologic institutions of Ukraine. Product Description popup.authors popup.nrat_date 2020-04-02 Close