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Registration Number

0309U000822, 0109U002628 , R & D reports

Title

To determine the cytogenetic criteria of aplasia and dysplasia of hemopoiesis in children

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Дослідження каріотипу гемопоетичних клітин при мієлодиспластичних синдромах та набутих апластичних анеміях у дітей

Head

Drozdova V. D.,

Registration Date

11-12-2009

Organization

State Institution "Institute of Haematology and Transfusiology AMS Ukraine"

Description

Object of research: воne marrow cells in 24 children with acquired aplastic anemia (AA) and in 17 children with myelodysplastic syndrome (MDS) were done. There were used karyotyping of differential staining chromosomes, morphological and histological methods. The normal karyotype in АА and MDS were found in 43,5% and 5,6% сases, respectively. The basic mechamism of gemone rearrangement were loso of genetic materials like monosomy and deletion. In АА were established more often the cases with mosaic karyotype. The structural rearrangemetns in AA and MDS more oftenwere involved chromosomes 11, 9, 3 and 16. Medicine.

Product Description

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Андреєва С.В.
Дроздова В.Д.
Кавардакова Н.В.
Стеблина В.Є.