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Information × Registration Number 0309U000861, 0109U001563 , R & D reports Title The investigation of ionizing radiation modificational effect on chromosome stability in somatic cells of a human by means of testing mutagenic exposure of bleomycin popup.stage_title Дослідження фонової та індукованої блеоміцином in vitro частоти та спектру аберацій хромосом в лімфоцитах периферичної крові осіб, які приймали участь у ліквідації аварії на ЧАЕС та працювали в 30-км зоні Head Pilinskaya Maria, Доктор медичних наук Registration Date 24-12-2009 Organization Research Centre for Radiation Medicine popup.description2 Object: human blood lymphocytes . The Purpose: to investigate the modifying influence of ionizing radiation on chromosome stability in somatic cells of Chornobyl cleanup workers and personnel of 30-km zone with the help of testing mitogenic exposure by bleomycin. The мethods: cytogenetics. The results: With the help of modifying by us "G2-bleomycin sensitivity assay" the investigation of hidden chromosome instability in unexposed donors and in persons with different intensity of radiation exposure had been fulfilled. In all examined groups the individual levels of chromosome aberrations varied in wide range and didn't depend on their initial background values. Maximal frequency of cases (46.7%) hypersensitive to testing bleomycin exposure had been identified among patients recovered from acute radiation sickness. In control groups frequencies of individuals with hidden chromosome instability were quite the same and didn't exceed 33.3%. Region of application: radiation genetic. Product Description popup.authors popup.nrat_date 2020-04-02 Close