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Information × Registration Number 0309U004257, 0109U001568 , R & D reports Title Estimation of chronic lymphocytic leukemia risks among the contingents suffered due to Chernobyl catastrophe on the basis of investigation of gene coding the protein of reparation polymorphism popup.stage_title Визначити поліморфізм генів, що кодують білки репарації, в групі хворих на хронічну лімфоцитарну лейкемію Head Chumak Anatoliy Andriyovych, Доктор медичних наук Registration Date 29-12-2009 Organization State Institution "Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine" popup.description2 The aim of work - to find association between polymorphisms of DNA repair genes and development of chronic lymphocytic leukemia in patients who suffered due to Chornobyl NPP catastrophe for early detection of risk group patients. The object of study: 179 chronic lymphocytic leukemia (CLL) patients, including irradiated 49 patients. The study of polymorphisms of DNA repair genes (XRCC1, XPD, XRCC3) use polymerase chain reaction and restriction of products was performed. The main results: it was detected the frequencies of XRCC1-199, XPD-751, and XRCC3-241 polymorphisms in CLL patients that did not differed significantly from literature data. The association of GG XRCC1 genotype and Richter transformation under treatment and protective influence of GG XPD genotype on CLL course were found. Some differences in frequency of separate polymorphisms depend on radiation anamnesis of patients were revealed that need confirmation on larger cohort of patients. Product Description popup.authors popup.nrat_date 2020-04-02 Close