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Information × Registration Number 0311U003958, 0110U006740 , R & D reports Title Molecular design and synthesis of bioactive calixarene derivatives popup.stage_title Проведення молекулярного дизайну і синтезу біологічно активних похідних каліксаренів Head Kalchenko Vitaliy Ivanovich, Доктор хімічних наук Registration Date 23-11-2011 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 With the aim of experimental verification of computer modeling results of intermolecular interactions which are characteristic for calix-subfragment-1 myosin complexes of smooth muscle of the uterus (performed in Palladin Institute of biochemistry) and in order to create effective criterion for interpretation of results calixarenes docking, the known methods of synthesis were improved and new stereoselective cone-calix[4]arene methods of synthesis with one, two or four biofornic hydroxyphosphonic and methylenbisphosphonic acids fragments were developed. The stereochemical and stereodynamic features of the synthesized compounds were investigated. Their ability to self-association in solution was established. Product Description popup.authors Вишневський Сергій Григорович Драпайло Андрій Богданович Кальченко Віталій Іванович Матвєєв Юрій Іванович Родік Роман Васильович Рубан Олександр Володимирович Черенок Сергій Олексійович Ющенко Олександр Анатолійович popup.nrat_date 2020-04-02 Close