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Information × Registration Number 0312U003428, 0109U002117 , R & D reports Title The investigation of mitochondria and plasma membrane ion channels role in vasospasm and myocardial dysfunction development popup.stage_title Вивчення ролі мітохондрій і мітохондріальної пори у розвитку артеріального вазоспазму різного генезу і міокардіальної дисфункції в умовах in vitro та in vivo. Head Soloviev A., Registration Date 14-06-2012 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 The results of studies that were conducted on isolated hearts of spontaneously hypertensive rats, indicate the ability fosfotydylholinovyh liposomes to restore contractile activity of myocardium that has suffered violations influenced the course of chronic hypertension. For vascular smooth muscle cells of rat aorta with hypertension found henetychnodeterminovanoyu decrease calcium sensitivity of the action of rotenone - an inhibitor of electron transport in respiratory chain. Shown that hypertension caused by total external ?-irradiation of rats at a dose of 6 December 9 th and 30 th day, leading to slower processes enerhoproduktyvnosti mitochondria. Diazoxide (activator of K + ATP channels) in a dose of 1 x10-4 mol in experiments in vitro in isolated mitochondria causes the hearts of intact animals to accelerate respiration in states 2 and 4 by Chance, slow breathing, which is associated with oxidative phosphorylation, decreased respiratory factor, reducing the process of synthesis of ATP. Against the background radiation diazoxide hardly changes the course of mitochondrial respiration. Under conditions of hypoxia in rat small intrapulmonary arteries seen sharp increases in their tone, which is endothelium-dependent and largely depends on the prior constriction of vascular preparations. Product Description popup.authors Іванова Ірина Володимирівна Бойцова Людмила Василівна Данова Ірина Владиславівна Добреля Наталія Володимирівна Зеленський Сергій Миколайович Кізуб Ігор Володимирович Мончак Ігор Леонідович Паршиков Олександр Вікторович Стрелков Євген Валентинович Тишкін Сергій Михайлович Хромов Олександр Станіславович popup.nrat_date 2020-04-02 Close