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Information × Registration Number 0313U005161, 0108U002098 , R & D reports Title Нemodynamic, metabolic and genetic aspects of treatment of patients with an arterial hypertension with application of calcium antagonists, ACE inhibitors, аngiotensin II receptor antagonists, ?-adrenoblockers. popup.stage_title Гемодинамічні, метаболічні та генетичні аспекти лікування хворих на артеріальну гіпертензію із застосуванням антагоністів кальцію, інгібіторів АПФ, блокаторів рецепторів ангіотензину ІІ, ?-адреноблокаторів. Head Bilets'kyi Semen Vissarionovych, Registration Date 11-04-2013 Organization Bukovinian State Medical University popup.description2 3.Duration of EAH is from 1 to 30 years. The control group was formed with 74 practically healthy persons representative by age and sex. Objective of the work: To improve the treatment of EAH depending on the genes polymorphisms of angiotensin-converting enzyme I / D, angiotensin II receptor type-1 A1166C, endothelial NO-synthase T894G, peroxisome proliferator-activated receptor ?2-Pro12Ala, ?1-adrenoceptor Arg389Gly, changes of the hemodynamic, metabolic indicators, ecosystem intestinal microbiota and immune reactivity with subsequent therapeutic correction, including pharmacogenetic determination. Research methods: general clinical, instrumental, biochemical, genetic, immunological, immunoenzymatic, microbiology, statistics. Designed by the scheme sensitivity of patients with EAH to antihypertensive drugs of the first line depending on the genotype of the analysed genes, carried individual pharmacogenetic determination of the treatment correction that significantly increased its effectiveness. Found that the use of S-amlodipine and its combination with lisinopril in patients with EAH effectively decreased blood pressure, indicators of lipid peroxidation, increased antioxidant protection and improves the status of hemostasis and proteolysis, characterized by a low frequency of occurrence of edemas. The results of scientific research put into the practice of health care institutions and used in higher medical educational process in Ukraine. Product Description popup.authors Білецький Семен Віссаріонович Казанцева Тетяна Василівна Кушнір Оксана Василівна Мельничук Лариса Василівна Петринич Оксана Анатоліївна Сидорчук Лариса Петрівна Соколенко Аліна Андріївна Урсуляк Юлія Віталіївна popup.nrat_date 2020-04-02 Close