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Information × Registration Number 0314U004012, 0109U003913 , R & D reports Title Mechanisms of generation and peculiarities of polymorbidity: clinical, functional and biochemical evaluation of associated internal diseases, the methods of differentiated correction popup.stage_title Механізми формування та особливості поліморбідності: клінічна, функціональна та біохімічна оцінка перебігу поєднаної патології внутрішніх органів, методи диференційованої корекції Head Khukhlina Oksana Svyatoslavivna, Доктор медичних наук Registration Date 23-01-2014 Organization Bukovinian State Medical University popup.description2 Objective: To define general facts and features of pathogenesis, functional state, clinical course of chronic diseases of the cardiovascular and respiratory systems in the concomitant endocrinal and by gastroenterological pathology, by studying of the complex changes of biochemical indexes, a vascular, thrombocyte and plasma hemostasis, system of antioxidant defense and specific immunological markers of diseases, to work up the early diagnostic and medicamental influenced programs in the conditions of comorbidity. Methods: analysis of anamnestic data, clinical, instrumental, biochemical, morphological, immunological, immunohistochemical, ultrasonography, statistical. The results: It was firstly established that meaningful predictors remodeling at the concentric hypertrophy of the left ventricle is changes of concentration of aldehyde- and ketonic derivatives of dinytrophenylhydrasons of neutral character, general cholesterol and activity of antithrombin ІІІ; at eccentric hypertrophy is a decline of activity of catalase. The predictors of risk of origin of stroke in patients with a hypertension with a concomitant diabetes mellitus 2 types in the Bukovina region come forward of the increase of index of body mass and thickness of walls of the left ventricle, increase of mass of myocardium and index of mass of myocardium weight. At ischemic heart disease with anemic syndrome there are substantial morphofunctional changes of red cells, the capacity of erythrocytes gets worse for deformation and permeability of membranes of erythrocytes goes down. Worsening of erythrocyte membranes deformation grows with the degree of weight of anemia. The electrodeless technique of registration of viscosity of blood allows to reduce the adaptive changes of this parameter at different diseases. Height of anisotropy of suspension of erythrocytes as an increase of statistical moments of 2-4th order of polarization maps of her laser images for patients with a metabolic syndrome correlates with arterial hypertension and ischemic heart disease with worsening of the structural-functional state of myocardium of the left ventricle and associated with growth of eventual diastole pressure. Including in the course of treatment of patients ischemic heart disease on the contrary the ground at the diabetes mellitus of 2th type and anemic syndrome of telmisartane by the use of traditional treatment, namely allows to improve the indexes of psychosomatic status and quality of life at this category of patients. Use of prebiotic lactulose in patients with concomitant atherosclerotic injury of mesenteric vessels and dysbacteriosis of bowel assists in updating of normobyocenosis by the "survival" of own Bifid- and Lactobacilli, reductions of contamination of cavity pathogenic flora, that in turn, assists the decline of the endotoxic loading. Product Description popup.authors Андрусяк Олександр Васильович Антонів Альона Андріївна Антофійчук Микола Петрович Воєвідка Оксана Степанівна Гайдичук Володимир Стефанович Горбатюк Ірина Борисівна Каньовська Людмила Володимирівна Каушанська Олена Вячеславівна Квасницька Ольга Борисівна Микитюк Орися Юріївна Нечіпай Жанна Аурелівна Павлюкович Наталія Дмитрівна Ткач Єлизавета Петрівна Трефаненко Ірина Валентинівна Хухліна Оксана Святославівна Чурсіна Тамара Яківна Шаплавський Микола Володимирович Шоріков Євген Іванович Шорікова Діна Валентинівна Шумко Галина Іванівна popup.nrat_date 2020-04-02 Close