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Information × Registration Number 0314U004070, 0109U003982 , R & D reports Title Diagnosis, prognosis and therapy of cardiovessel disoders in children with cardovessel diseases popup.stage_title Діагностика, прогнозування та терапія серцево-судинних порушень у дітей з хронічною бронхолегеневою патологією Head Legenko Genady Alexandrovich, Registration Date 06-03-2014 Organization Zaporozhye State Medical University. Department of psychiatry popup.description2 Examined 319 children with chronic obstructive pulmonary disease (COPD) aged 3-16 years (60 children with cystic fibrosis and pancreatic insufficiency, 139 patients with persistent asthma and 120 children with recurrent bronchitis). Determined that 52% of children with asthma, 56 % of patients with recurrent bronchitis and 64 % of children with cystic fibrosis had change of morphological and functional performance of the heart and intracardiac hemodynamics. The most unfavorable age period for development of cardio-vascular disorders are the ages of 3-6 years and 12-16 years. Cardiovascular disorders in children with COPD take place against the background of stress functioning of sympathetic nervous system, endothelial dysfunction, initial insufficiency of the adrenal glucocorticoid synthesis and increased content of the acute phase inflammatory proteins. The development of left ventricular hypertrophy in children with COPD accompanied by activation of the renin-angiotensin-aldosterone system. Early markers of cardiovascular disorders in children with COPD are elevated levels of serum NTproBNP, activation of the synthesis of transforming growth factor-beta1 and insulin-like growth factor-1, decrease of insulin level. Based on the results proved the feasibility of incorporating therapy in such patients drugs from the group of ACE inhibitors and L-arginine. Product Description popup.authors Гиря Олена Максимівна Каменщик Андрій Володимирович Пашкова Олена Єгорівна popup.nrat_date 2020-04-02 Close