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Information × Registration Number 0316U004056, 0116U008793 , R & D reports Title Development methods of pyrazolo[3,4-c]isoquinoline structure heteroarylation in benzene ring popup.stage_title Розробка методів гетарилювання структури піразоло[3,4-c]ізохіноліну за бензеновим циклом Head Bogdan Natalya Mikhailovna, Registration Date 16-12-2016 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 Object: derivatives of pyrazolo [3,4-c]isoquinoline with heteroaryl substituent. Objective: development of modern preparative methods of pyrazolo [3,4-c]isoquinoline synthesis with heteroaryl substituents in the benzene ring of original condensed heterocyclic molecule as part of the technical solutions for the industrial production of a wide range of pyrazolo [3,4-c] isoquinolines. Methods: organic synthesis, metal-catalysis of organic reactions, physical and chemical methods of research. Theoretical and practical results: The observed high activity derivative of said heterocyclic system to inhibit kinases along with extremely low toxicity stimulated currently developing ways to a wide variation in their structure in order to obtain leading molecules for anticancer agents, including joining heterocyclic substituent as a means of optimizing the structure of molecules at the stage of "structure - activity". Novelty: arylation derivative pyrazolo [3,4-c] isoquinoline previously researched. Scope: research and educational institutions, pharmaceutical plants. Product Description popup.authors Богза Сергій Леонідович Суйков Сергій Юрійович popup.nrat_date 2020-04-02 Close