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Information × Registration Number 0319U002010, 0118U006815 , R & D reports Title Study of influence of liposomal form of nitric oxide on potassium conduction of smooth muscle of vessels. popup.stage_title Вивчення впливу ліпосомальної форми оксиду азоту на калієву провідність гладких м'язів судин. Head Zholos Alexandr, Доктор біологічних наук Registration Date 28-01-2019 Organization Taras Shevchenko Kiev University popup.description2 Adding an external solution of liposomal nitrogen oxide (LFNO) in the concentration range from 10-8 to 10-5 M cumulatively caused a powerful activation of the MaxiK channels, which was manifested in the emergence of series of opening channels alternating with its short closures. The main mechanism of action of LFNO on the MaxiK channel of MMC pulmonary arteries of rats is to increase the probability of an open state of the channel. The uterine smooth muscle had a different response to the use of LFNO (3 ?g / ml). Those strips that did not generate spontaneous phase activity showed a decrease in tension. Strips that had spontaneous phase activity responded to application of substance by decreasing the amplitude and frequency of contractions. In experiments using LFNO against the background of oxytocin, the oppressive effect of NO was not statistically significant.5481 Product Description popup.authors popup.nrat_date 2020-04-02 Close