Search academic texts

Registration Number

0319U002014, 0118U004009 , R & D reports

Title

Synthesis of new potentially active compounds based on urea and thiourea derivatives, prediction of their bioactivity.

popup.stage_title

Розробка методик синтезу нових похідних сечовини.

Head

Avdeenko Anatoly Petrovich, Кандидат хімічних наук

Registration Date

07-02-2019

Organization

Donbass State Engineering Academy

popup.description2

Object of research: N-substituted-N'-acylthioureas and products of their interaction with dinucleophiles. Objective of research: synthesis of derivatives of thiourea, study of their reactions with dinucleophiles; obtaining of new heterocyclic compounds based on the thiourea derivatives and determine of their possible biological activity using the PASS program. Research methods: physical and chemical methods for the investigation of compounds: IR, NMR 1H, NMR 13C spectroscopy, elemental analysis. Theoretical and practical results: The technique of synthesis of N aryl-N'-acyltiourea has been mastered. N-Aryl-N'-acyltioureas with different substituents in the structure have been synthesized. These compounds are the starting compounds in reactions of acylthioureas with dinucleophiles. Reactions of substituted thiourea with dinucleophiles: hydrazine, phenylhydrazine have been studied. It has been found that N-substituted-N'-acylthioureas are reacted with hydrazine to form substituted 3-amino-1,2,4-triazoles and N-substituted thioureas. The derivatives of carboxylic acids of the aromatic, heterocyclic and aliphatic series (derivatives of aryl, aralkyl, heteroaryl amines) can react under this scheme. The reaction of N-substituted-N'-acyltiourea with phenylhydrazine proceeds only with the most active acyloxyureas and leads to the selective formation of substituted 1-phenyl 3-amino-1,2,4-triazoles. The structural fragment "six-member cycle - one atom - five-member cycle" is characteristic of many biologically active substances. Therefore, according to the concept of molecular similarity ("similar structures have similar properties") it can be assumed that the resulting substituted 3-amino-1,2,4-triazoles and 1-phenyl 3-amino-1,2,4-triazoles are potentially biologically active compounds.

Product Description

popup.authors

Авдєєнко Анатолій Петрович
Коновалова Світлана Олексіївна

popup.nrat_date

2020-04-02