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Information × Registration Number 0319U002014, 0118U004009 , R & D reports Title Synthesis of new potentially active compounds based on urea and thiourea derivatives, prediction of their bioactivity. popup.stage_title Розробка методик синтезу нових похідних сечовини. Head Avdeenko Anatoly Petrovich, Кандидат хімічних наук Registration Date 07-02-2019 Organization Donbass State Engineering Academy popup.description2 Object of research: N-substituted-N'-acylthioureas and products of their interaction with dinucleophiles. Objective of research: synthesis of derivatives of thiourea, study of their reactions with dinucleophiles; obtaining of new heterocyclic compounds based on the thiourea derivatives and determine of their possible biological activity using the PASS program. Research methods: physical and chemical methods for the investigation of compounds: IR, NMR 1H, NMR 13C spectroscopy, elemental analysis. Theoretical and practical results: The technique of synthesis of N aryl-N'-acyltiourea has been mastered. N-Aryl-N'-acyltioureas with different substituents in the structure have been synthesized. These compounds are the starting compounds in reactions of acylthioureas with dinucleophiles. Reactions of substituted thiourea with dinucleophiles: hydrazine, phenylhydrazine have been studied. It has been found that N-substituted-N'-acylthioureas are reacted with hydrazine to form substituted 3-amino-1,2,4-triazoles and N-substituted thioureas. The derivatives of carboxylic acids of the aromatic, heterocyclic and aliphatic series (derivatives of aryl, aralkyl, heteroaryl amines) can react under this scheme. The reaction of N-substituted-N'-acyltiourea with phenylhydrazine proceeds only with the most active acyloxyureas and leads to the selective formation of substituted 1-phenyl 3-amino-1,2,4-triazoles. The structural fragment "six-member cycle - one atom - five-member cycle" is characteristic of many biologically active substances. Therefore, according to the concept of molecular similarity ("similar structures have similar properties") it can be assumed that the resulting substituted 3-amino-1,2,4-triazoles and 1-phenyl 3-amino-1,2,4-triazoles are potentially biologically active compounds. Product Description popup.authors Авдєєнко Анатолій Петрович Коновалова Світлана Олексіївна popup.nrat_date 2020-04-02 Close