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Information × Registration Number 0399U002982, 0198U003159 , R & D reports Title New approaches to optimizing cancer treatment for mielotoxicity and immunodehression prevention popup.stage_title Дослідження ефективності проведення протипухлинної терапії з урахуванням добових коливань проліферативної активності кісткового мозку і функціювання імунокомпетентних клітин та експериментальне обгрунтування можливості інтенсифікації хіміотерапії при циркадному режимі її проведення Head Sukhina O.M., Registration Date 03-06-2000 Organization Grigor'ev Institut for Medical Radiology popup.description2 . Object of research. 11 patients with uterine cancer; 14 patients with ovary cancer; 10 healthy women; 32 rats. Objective. To develop the technology of radio-and cytostatic cancer treatment for myelotoxicity minimizing and prevention immunity complications. Methods and Equipment. Clinical, morphological, immunological, mathematical, statistical, microscopes, spectrophotometer. Results. Experimental studies have documented that toxicity of cyclophosphamide for leucopoiesis is time-of-day depended in rats. An intraperitoneal injection of cyclophosphamide in late dark period (proliferative activity in bone marrow decreased) allows to increase drug single dose with preservation of leucopoiesis. Clinical data show, that chronomodulation of cytostatics given singly or in combination to women with ovary and uterine cancer allows significantly diminish myelo-and clinical toxicity. Novelty. It was elaborated the scientific and methodological approaches to cytostatic therapy administration in cancer patients to achieve the minimum myelotoxicity and prevent immunity complications Efficacy. It has improved tolerance of the cancer treatment with rising of cancer patients life quality and treatment efficacy. Sphere of application Medical radiology, oncology. Product Description popup.authors popup.nrat_date 2020-04-03 Close