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Information × Registration Number 0399U003663, 0196U001833 , R & D reports Title The investigation of delta-sleep inducing peptide influence in case of its alone and combined administration with the substances modulating norepinephrinergic and GABA- ergic activity on the naloxone-induced abstinent signs in kindled rats popup.stage_title Вивчити механізми розвитку експериментального абстинентного синдрому на основі визначення функціональних змін, що викликані налоксоном, з метою розробки фармакологічних методів припинення проявів абстиненції Head Shandra Oleksij Antonovych, Registration Date 14-09-2000 Organization Odessa state medical university popup.description2 It was shown firstly that delta-sleep including peptide administration in relatively small dose (0.1mg/kg, i.p.) failed the abstinent signs development in pharmocologically and electrically kindled rats as well as peptide relatively big dose (1.0 mg/kg, i.p.) lead to the abstinent signs inhancening in kindled rats. The data obtained are in favour for n-opioid receptors provided proabstinent effects as well as k-opioid receptors provided the opposite ones. This result is the base for the new opioid receptor selective antagonist searching which might provide antiabstinent action Product Description popup.authors popup.nrat_date 2020-04-03 Close