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0400U000168,
к.мед.н.
23-12-1999
o
Systemic-regional proteolysis and humoral factors of protetion in estimatig prognosis of course and peculiarities of pathogenetic therapy in pneumonia
Smuglov Yevgen Pavlovych,
popup.head Кузнецов Микола Степанович
popup.opponent Чухрiєнко Неонiлла Дмитрiєвна
popup.opponent Ярош Олександр Михайлович
Об'єкт дослідження: 168 хворих на рiзнi варiанти пневмонiї. Мета дослідження: покрашення діагностики і підвищення ефективності лікування різних варіантів перебігу пневмонії на підставі визначення закономірностей змін плазмінових і неплазмінових протеїназ, їх інгібіторів і гуморальних факторів захисту в системному кровоплині і на регіонарному рівні. Методи: загальноприйняті медичні методи обстеження із захворюваннями органів дихання, статистичні методи. Теоретичні і практичні результати: встановлено роль порушення системно-регiонарного протеолiза i гуморальних факторiв захисту в патогенезi рiзних варiантiв перебiгу пневмонiї; обгрунтовано ефективність тiотриазолiну у хворих на пневмонiю. Новітність нововпроваджуваного: розробка лабораторних дiагностичних критерiiв прогнозу затяжного та ускладненного перебiгу пневмонii; запропоновано спосіб корекції антипротеїназного потенціалу у хворих на пневмонію, який заключається у застосуванні тіотриазоліну. Ступінь впровадження: тези,статті, рацiоналiзаторскi пропозицii. Ефективність: підвищення ефективності лікування на 18%. Сфера, галузь використання: медицина.
1999-12-23
2020-04-04
Updated: 2025-12-14
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