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0402U002215,
к.б.н.
20-06-2002
o
Investigation of the pacemaker activity of molluscan neurons and influence of triterpene saponins on it
Kostyuchenko Oksana Valentinovna,
popup.head Korenyuk I. I.
popup.opponent Шаповал Л. М.
popup.opponent Русяєв В. Ф.
Об'єкт - нейрони молюсків, мета - дослідити механізми генерації пейсмекерної активності в нервових клітинах та особливості дії тритерпенових глікозидів на активність нейронів; методи - внутрішньоклітинного відведення біопотенціалів, ізоляції нейронів, внутрішньоклітинної перфузії, фіксації потенціалу в конфігурації "ціла клітина"; новизна - досліджено природу пейсмекерної активності ідентифікованих нейронів, показано, що тривала гіперполяризація мембрани нейронів, яка викликана впливом монодесмозидних глікозидів, пов'язана з підвищеним виходом К+ із клітин; результати - вивчено механізм генерації пейсмекерної активності у нейронах молюска, досліджено вплив тритерпенових глікозидів на нейрональну мембрану; галузь - клінічна медицина.
2002-06-20
2020-04-04
Updated: 2025-12-08
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